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Target
LIM domain kinase 1
Ligand
BDBM50072662
Substrate
n/a
Meas. Tech.
ChEMBL_1467118 (CHEMBL3411315)
IC50
4000±n/a nM
Citation
 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J Med Chem 58:1846-61 (2015) [PubMed]  Article 
Target
Name:
LIM domain kinase 1
Synonyms:
LIM domain kinase 1 | LIMK-1 | LIMK1_RAT | Limk | Limk1
Type:
PROTEIN
Mol. Mass.:
72598.76
Organism:
Rattus norvegicus
Description:
ChEMBL_109573
Residue:
647
Sequence:
MRLTLLCCTWREERMGEEGSELPVCASCSQSIYDGQYLQALNADWHADCFRCCECSTSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVGGELKYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHIGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLASPVHTPSGQAGSSARQKPVLRSCSIDTSPGAGSLVSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLAGHLPLGPQLEQLERGFWETYRRGESSLPAHPEVPD
  
Inhibitor
Name:
BDBM50072662
Synonyms:
CHEMBL3407526
Type:
Small organic molecule
Emp. Form.:
C24H23FN6O2
Mol. Mass.:
446.4768
SMILES:
CC(C)NC(=O)c1cccc(NC(=O)Nc2ccc(cc2F)-c2ncnc3[nH]cc(C)c23)c1
Structure:
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