Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Blk
Ligand
BDBM50075730
Substrate
n/a
Meas. Tech.
ChEMBL_1473547 (CHEMBL3420426)
IC50
32±n/a nM
Citation
 Ellis, JM; Altman, MD; Bass, A; Butcher, JW; Byford, AJ; Donofrio, A; Galloway, S; Haidle, AM; Jewell, J; Kelly, N; Leccese, EK; Lee, S; Maddess, M; Miller, JR; Moy, LY; Osimboni, E; Otte, RD; Reddy, MV; Spencer, K; Sun, B; Vincent, SH; Ward, GJ; Woo, GH; Yang, C; Houshyar, H; Northrup, AB Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors. J Med Chem 58:1929-39 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Blk
Synonyms:
B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk
Type:
Protein
Mol. Mass.:
57711.88
Organism:
Homo sapiens (Human)
Description:
P51451
Residue:
505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP
  
Inhibitor
Name:
BDBM50075730
Synonyms:
CHEMBL3415599
Type:
Small organic molecule
Emp. Form.:
C18H24N6O4S
Mol. Mass.:
420.486
SMILES:
COc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: