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Target
Histone acetyltransferase GCN5
Ligand
BDBM50076444
Substrate
n/a
Meas. Tech.
ChEMBL_1473889 (CHEMBL3419140)
IC50
11000±n/a nM
Citation
 Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem 58:2091-113 (2015) [PubMed]  Article 
Target
Name:
Histone acetyltransferase GCN5
Synonyms:
ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9
Type:
PROTEIN
Mol. Mass.:
51069.24
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_100832
Residue:
439
Sequence:
MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID
  
Inhibitor
Name:
BDBM50076444
Synonyms:
CHEMBL1609841
Type:
Small organic molecule
Emp. Form.:
C20H18N4O3S
Mol. Mass.:
394.447
SMILES:
COc1ccc(cc1)N1C(=O)CC(Sc2n[nH]c(n2)-c2ccc(C)cc2)C1=O
Structure:
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