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Target
Methionine aminopeptidase 1
Ligand
BDBM50316031
Substrate
n/a
Meas. Tech.
ChEMBL_1471054 (CHEMBL3420499)
Ki
111600±n/a nM
Citation
 Arya, T; Reddi, R; Kishor, C; Ganji, RJ; Bhukya, S; Gumpena, R; McGowan, S; Drag, M; Addlagatta, A Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases. J Med Chem 58:2350-7 (2015) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM50316031
Synonyms:
CHEMBL1090366 | amino(phenyl)methylphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H10NO3P
Mol. Mass.:
187.133
SMILES:
NC(c1ccccc1)P(O)(O)=O
Structure:
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