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Target
Heme oxygenase 2
Ligand
BDBM50079990
Substrate
n/a
Meas. Tech.
ChEMBL_1470661 (CHEMBL3420440)
IC50
900±n/a nM
Citation
 Salerno, L; Pittalą, V; Romeo, G; Modica, MN; Marrazzo, A; Siracusa, MA; Sorrenti, V; Di Giacomo, C; Vanella, L; Parayath, NN; Greish, K Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines. Eur J Med Chem 96:162-72 (2015) [PubMed]  Article 
Target
Name:
Heme oxygenase 2
Synonyms:
HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2
Type:
Enzyme
Mol. Mass.:
35754.99
Organism:
Rattus norvegicus (rat)
Description:
HO-2 obtained from rat brain was used in enzyme assays.
Residue:
315
Sequence:
MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENWEEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTGEGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAGSMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILAASVALVAGLLAWYYM
  
Inhibitor
Name:
BDBM50079990
Synonyms:
CHEMBL3415252
Type:
Small organic molecule
Emp. Form.:
C14H14ClN3S2
Mol. Mass.:
323.864
SMILES:
Clc1ccc2sc(SCCCCn3ccnc3)nc2c1
Structure:
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