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Target
Coagulation factor X
Ligand
BDBM50080133
Substrate
n/a
Meas. Tech.
ChEMBL_1471173 (CHEMBL3421304)
IC50
810±n/a nM
Citation
 Zhao, Y; Jiang, M; Zhou, S; Wu, S; Zhang, X; Ma, L; Zhang, K; Gong, P Design, synthesis and structure-activity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors. Eur J Med Chem 96:369-80 (2015) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
F10 | FA10_RABIT
Type:
PROTEIN
Mol. Mass.:
53951.21
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1471174
Residue:
490
Sequence:
MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
  
Inhibitor
Name:
BDBM50080133
Synonyms:
CHEMBL3415977
Type:
Small organic molecule
Emp. Form.:
C23H23ClN4O3S
Mol. Mass.:
470.972
SMILES:
Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)-n1cccc1CN1CCC1 |r|
Structure:
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