Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50080107
Substrate
n/a
Meas. Tech.
ChEMBL_1471174 (CHEMBL3421305)
IC50
1030±n/a nM
Citation
 Zhao, Y; Jiang, M; Zhou, S; Wu, S; Zhang, X; Ma, L; Zhang, K; Gong, P Design, synthesis and structure-activity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors. Eur J Med Chem 96:369-80 (2015) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
F10 | FA10_RABIT
Type:
PROTEIN
Mol. Mass.:
53951.21
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1471174
Residue:
490
Sequence:
MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
  
Inhibitor
Name:
BDBM50080107
Synonyms:
CHEMBL3415998
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O3S2
Mol. Mass.:
505.053
SMILES:
CCN(CC)Cc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O |r|
Structure:
Search PDB for entries with ligand similarity: