Reaction Details Report a problem with these data
Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50080822
Substrate
n/a
Meas. Tech.
ChEMBL_1475234 (CHEMBL3425032)
Kd
9.3±n/a nM
Citation
 Waterson, AG; Kennedy, JP; Patrone, JD; Pelz, NF; Feldkamp, MD; Frank, AO; Vangamudi, B; Souza-Fagundes, EM; Rossanese, OW; Chazin, WJ; Fesik, SW Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett 6:140-5 (2015) [PubMed]  Article 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50080822
Synonyms:
CHEMBL3422475
Type:
Small organic molecule
Emp. Form.:
C26H17Cl2N5O4S
Mol. Mass.:
566.415
SMILES:
OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3nc(=O)o[nH]3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Structure:
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