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Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50080861
Substrate
n/a
Meas. Tech.
ChEMBL_1475234 (CHEMBL3425032)
Kd
70±n/a nM
Citation
 Waterson, AG; Kennedy, JP; Patrone, JD; Pelz, NF; Feldkamp, MD; Frank, AO; Vangamudi, B; Souza-Fagundes, EM; Rossanese, OW; Chazin, WJ; Fesik, SW Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett 6:140-5 (2015) [PubMed]  Article 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50080861
Synonyms:
CHEMBL3422462
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2N3O4S
Mol. Mass.:
502.37
SMILES:
OC(=O)c1cc(-c2ccc(CNS(=O)(=O)c3ccccc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Structure:
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