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Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
LigandBDBM50082128
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1475280
IC50 575±n/a nM
Citation Boyd, SBrookfield, JLCritchlow, SECumming, IACurtis, NJDebreczeni, JDegorce, SLDonald, CEvans, NJGroombridge, SHopcroft, PJones, NPKettle, JGLamont, SLewis, HJMacFaull, PMcLoughlin, SBRigoreau, LJSmith, JMSt-Gallay, SStock, JKTurnbull, APWheatley, ERWinter, JWingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem58:3611-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Synonyms:6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2
Type:Enzyme
Mol. Mass.:59620.59
Organism:Homo sapiens (Human)
Description:Q16875
Residue:520
Sequence:
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50082128
NameBDBM50082128
Synonyms:CHEMBL3422654
TypeSmall organic molecule
Emp. Form.C18H17N5O3
Mol. Mass.351.3593
SMILESN[C@@H](CO)C(=O)Nc1ccc(Oc2ccc3[nH]c(N)c(C#N)c3c2)cc1 |r|
Structure
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