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Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
LigandBDBM50082197
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1475278
IC50>100000±n/a nM
Citation Boyd, SBrookfield, JLCritchlow, SECumming, IACurtis, NJDebreczeni, JDegorce, SLDonald, CEvans, NJGroombridge, SHopcroft, PJones, NPKettle, JGLamont, SLewis, HJMacFaull, PMcLoughlin, SBRigoreau, LJSmith, JMSt-Gallay, SStock, JKTurnbull, APWheatley, ERWinter, JWingfield, J Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem58:3611-25 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Synonyms:6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | 6PF-2-K/Fru-2,6-P2ase 1 | 6PF-2-K/Fru-2,6-P2ase liver isozyme | F6PK | Fructose-2,6-bisphosphatase | PFK/FBPase 1 | PFKFB1 | PFRX
Type:PROTEIN
Mol. Mass.:54681.17
Organism:Homo sapiens (Human)
Description:ChEMBL_109606
Residue:471
Sequence:
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
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BDBM50082197
NameBDBM50082197
Synonyms:CHEMBL3422665
TypeSmall organic molecule
Emp. Form.C22H22N4O2
Mol. Mass.374.4357
SMILESCCn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@H]4CCCN4)cc3)ccc12 |r|
Structure
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n/a