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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50082293
Substrate
n/a
Meas. Tech.
ChEMBL_1475489 (CHEMBL3424482)
IC50
706±n/a nM
Citation
 Hu, Q; Kunde, J; Hanke, N; Hartmann, RW Identification of 4-(4-nitro-2-phenethoxyphenyl)pyridine as a promising new lead for discovering inhibitors of both human and rat 11ß-Hydroxylase. Eur J Med Chem 96:139-50 (2015) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_RAT | Cyp11b-1 | Cyp11b1 | Cytochrome P450 11B | Cytochrome P450 11B1
Type:
PROTEIN
Mol. Mass.:
57478.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1475489
Residue:
499
Sequence:
MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFLTFRPVS
  
Inhibitor
Name:
BDBM50082293
Synonyms:
CHEMBL3421785
Type:
Small organic molecule
Emp. Form.:
C20H18N2O3
Mol. Mass.:
334.3685
SMILES:
[O-][N+](=O)c1ccc(Cc2cccnc2)c(OCCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: