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Target
Monoglyceride lipase
Ligand
BDBM50083674
Substrate
n/a
Meas. Tech.
ChEMBL_1474894 (CHEMBL3423530)
IC50
83000±n/a nM
Citation
 Aghazadeh Tabrizi, M; Baraldi, PG; Ruggiero, E; Saponaro, G; Baraldi, S; Romagnoli, R; Martinelli, A; Tuccinardi, T Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH). Eur J Med Chem 97:289-305 (2015) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50083674
Synonyms:
CHEMBL3422944
Type:
Small organic molecule
Emp. Form.:
C25H26ClN3O4
Mol. Mass.:
467.945
SMILES:
CCOC(=O)c1cc(-c2cccc(OC(=O)NC3CCCCC3)c2)n(n1)-c1ccc(Cl)cc1
Structure:
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