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Target
Sodium/nucleoside cotransporter 2
Ligand
BDBM50085527
Substrate
n/a
Meas. Tech.
ChEMBL_1477251 (CHEMBL3428943)
IC50
640±n/a nM
Citation
 Tatani, K; Hiratochi, M; Nonaka, Y; Isaji, M; Shuto, S Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett 6:244-8 (2015) [PubMed]  Article 
Target
Name:
Sodium/nucleoside cotransporter 2
Synonyms:
CNT2 | S28A2_HUMAN | SLC28A2
Type:
PROTEIN
Mol. Mass.:
71934.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1477251
Residue:
658
Sequence:
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
  
Inhibitor
Name:
BDBM50085527
Synonyms:
CHEMBL3427690
Type:
Small organic molecule
Emp. Form.:
C23H24N6O4
Mol. Mass.:
448.4745
SMILES:
Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc(cc3)-c3ccccc3)nc12 |r|
Structure:
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