Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50085593
Substrate
n/a
Meas. Tech.
ChEMBL_1477257 (CHEMBL3428949)
EC50
3.9±n/a nM
Citation
 Takano, R; Yoshida, M; Inoue, M; Honda, T; Nakashima, R; Matsumoto, K; Yano, T; Ogata, T; Watanabe, N; Hirouchi, M; Yoneyama, T; Ito, S; Toda, N Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist. ACS Med Chem Lett 6:266-70 (2015) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50085593
Synonyms:
CHEMBL3427703
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2O4
Mol. Mass.:
369.239
SMILES:
CCO[C@@H](CC(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Structure:
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