Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50086043
Substrate
n/a
Meas. Tech.
ChEMBL_1477925 (CHEMBL3429346)
IC50
>128000±n/a nM
Citation
 Nepomuceno, GM; Chan, KM; Huynh, V; Martin, KS; Moore, JT; O'Brien, TE; Pollo, LA; Sarabia, FJ; Tadeus, C; Yao, Z; Anderson, DE; Ames, JB; Shaw, JT Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ. ACS Med Chem Lett 6:308-12 (2015) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_BACSU | ftsZ
Type:
PROTEIN
Mol. Mass.:
40385.33
Organism:
Bacillus subtilis
Description:
ChEMBL_1470470
Residue:
382
Sequence:
MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG
  
Inhibitor
Name:
BDBM50086043
Synonyms:
CHEMBL3425679
Type:
Small organic molecule
Emp. Form.:
C21H23BrN4
Mol. Mass.:
411.338
SMILES:
CN(C)CCNc1nc(\C=C\c2ccc(Br)cc2)nc2ccc(C)cc12
Structure:
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