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TargetGlucagon-like peptide 1 receptor (GLP-1)
LigandBDBM50086593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1477109
Ki 2400±n/a nM
Citation Hoang, HNSong, KHill, TADerksen, DREdmonds, DJKok, WMLimberakis, CLiras, SLoria, PMMascitti, VMathiowetz, AMMitchell, JMPiotrowski, DWPrice, DAStanton, RVSuen, JYWithka, JMGriffith, DAFairlie, DP Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists. J Med Chem58:4080-5 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucagon-like peptide 1 receptor (GLP-1)
Name:Glucagon-like peptide 1 receptor
Synonyms:GLP-1 receptor | GLP-1-R | GLP-1R | Glucagon-like peptide 1 receptor
Type:Enzyme
Mol. Mass.:53035.78
Organism:Homo sapiens (Human)
Description:P43220
Residue:463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50086593
NameBDBM50086593
Synonyms:CHEMBL3426291
TypeSmall organic molecule
Emp. Form.C69H87FN14O18S2
Mol. Mass.1483.64
SMILESCCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H]2CSSC[C@@H](NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N2)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(N)=O)cc1 |r|
Structure
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