Reaction Details Report a problem with these data
Target
Phosphatidylinositol 4-kinase type 2-alpha
Ligand
BDBM50005005
Substrate
n/a
Meas. Tech.
ChEMBL_1477992 (CHEMBL3429700)
IC50
>100000±n/a nM
Citation
 Mejdrová, I; Chalupská, D; Kögler, M; ?ála, M; Placková, P; Baumlová, A; Hrebabecký, H; Procházková, E; Dejmek, M; Guillon, R; Strunin, D; Weber, J; Lee, G; Birkus, G; Mertlíková-Kaiserová, H; Boura, E; Nencka, R Highly Selective Phosphatidylinositol 4-Kinase IIIß Inhibitors and Structural Insight into Their Mode of Action. J Med Chem 58:3767-93 (2015) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase type 2-alpha
Synonyms:
P4K2A_HUMAN | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha | Phosphatidylinositol 4-kinase type II-alpha
Type:
PROTEIN
Mol. Mass.:
54030.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104812
Residue:
479
Sequence:
MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
  
Inhibitor
Name:
BDBM50005005
Synonyms:
CHEMBL2397317
Type:
Small organic molecule
Emp. Form.:
C22H29N5O3
Mol. Mass.:
411.4974
SMILES:
COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12
Structure:
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