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Target
Scavenger receptor class B member 1
Ligand
BDBM50088273
Substrate
n/a
Meas. Tech.
ChEMBL_1476710 (CHEMBL3429061)
IC50
230±n/a nM
Citation
 Dockendorff, C; Faloon, PW; Germain, A; Yu, M; Youngsaye, W; Nag, PP; Bennion, M; Penman, M; Nieland, TJ; Dandapani, S; Perez, JR; Munoz, B; Palmer, MA; Schreiber, SL; Krieger, M Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2594-8 (2015) [PubMed]  Article 
Target
Name:
Scavenger receptor class B member 1
Synonyms:
SCRB1_MOUSE | SR-BI | Scarb1 | Scavenger receptor class B member 1 | Srb1
Type:
PROTEIN
Mol. Mass.:
56761.39
Organism:
Mus musculus
Description:
ChEMBL_103999
Residue:
509
Sequence:
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
  
Inhibitor
Name:
BDBM50088273
Synonyms:
CHEMBL3427483
Type:
Small organic molecule
Emp. Form.:
C24H30F2N6O4
Mol. Mass.:
504.5296
SMILES:
CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OC(F)(F)Oc2c1)C(=O)NC1CCCC1
Structure:
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