Reaction Details Report a problem with these data
Target
Scavenger receptor class B member 1
Ligand
BDBM50323654
Substrate
n/a
Meas. Tech.
ChEMBL_1476715 (CHEMBL3429066)
IC50
770±n/a nM
Citation
Dockendorff, C; Faloon, PW; Germain, A; Yu, M; Youngsaye, W; Nag, PP; Bennion, M; Penman, M; Nieland, TJ; Dandapani, S; Perez, JR; Munoz, B; Palmer, MA; Schreiber, SL; Krieger, M Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. Bioorg Med Chem Lett 25:2594-8 (2015) [PubMed] Article
More Info.:
Target
Name:
Scavenger receptor class B member 1
Synonyms:
SCRB1_MOUSE | SR-BI | Scarb1 | Scavenger receptor class B member 1 | Srb1
Type:
PROTEIN
Mol. Mass.:
56761.39
Organism:
Mus musculus
Description:
ChEMBL_103999
Residue:
509
Sequence:
MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNVRIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVNITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMTLALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGVFTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFSPEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTCRFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSLYIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLGLGGLLLLVPIICQLRSQEKCFLFWSGSKKGSQDKEAIQAYSESLMSPAAKGTVLQEAKL
Inhibitor
Name:
BDBM50323654
Synonyms:
CHEMBL1208829 | N-(5-tert-butyl-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide
Type:
Small organic molecule
Emp. Form.:
C30H37N3O7S
Mol. Mass.:
583.696
SMILES:
COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C