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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM50343431
Substrate
n/a
Meas. Tech.
ChEMBL_1497041 (CHEMBL3580016)
Ki
7500±n/a nM
Citation
 Tintori, C; La Sala, G; Vignaroli, G; Botta, L; Fallacara, AL; Falchi, F; Radi, M; Zamperini, C; Dreassi, E; Dello Iacono, L; Orioli, D; Biamonti, G; Garbelli, M; Lossani, A; Gasparrini, F; Tuccinardi, T; Laurenzana, I; Angelucci, A; Maga, G; Schenone, S; Brullo, C; Musumeci, F; Desogus, A; Crespan, E; Botta, M Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. J Med Chem 58:4590-609 (2015) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM50343431
Synonyms:
1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-Nphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1775035
Type:
Small organic molecule
Emp. Form.:
C25H27ClN6OS
Mol. Mass.:
495.039
SMILES:
ClC(Cn1ncc2c(Nc3ccccc3)nc(SCCN3CCOCC3)nc12)c1ccccc1
Structure:
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