Reaction Details Report a problem with these data
Target
Urotensin-2 receptor
Ligand
BDBM50089668
Substrate
n/a
Meas. Tech.
ChEMBL_1496212 (CHEMBL3579096)
EC50
21±n/a nM
Citation
 Dufour-Gallant, J; Chatenet, D; Lubell, WD De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-oneż-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo. J Med Chem 58:4624-37 (2015) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42725.34
Organism:
RAT
Description:
Urotensin-II UTS2R RAT::P49684
Residue:
386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
  
Inhibitor
Name:
BDBM50089668
Synonyms:
CHEMBL3577305
Type:
Small organic molecule
Emp. Form.:
C30H30N4O4
Mol. Mass.:
510.5836
SMILES:
NCCCC[C@@H]1N=C(c2[nH]c(cc2N(CCc2ccc(O)cc2)C1=O)C(O)=O)c1ccc2ccccc2c1 |r,c:6|
Structure:
Search PDB for entries with ligand similarity: