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TargetLactate dehydrogenase A (LDHA)
LigandBDBM50089923
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1499429
IC50 30±n/a nM
Citation Labadie, SDragovich, PSChen, JFauber, BPBoggs, JCorson, LBDing, CZEigenbrot, CGe, HHo, QLai, KWMa, SMalek, SPeterson, DPurkey, HERobarge, KSalphati, LSideris, SUltsch, MVanderPorten, EWei, BXu, QYen, IYue, QZhang, HZhang, XZhou, A Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett25:75-82 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lactate dehydrogenase A (LDHA)
Name:L-lactate dehydrogenase A chain
Synonyms:Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | Renal carcinoma antigen NY-REN-59
Type:Protein
Mol. Mass.:36694.85
Organism:Homo sapiens (Human)
Description:P00338::PDB Code: 4ajp
Residue:332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50089923
NameBDBM50089923
Synonyms:CHEMBL3581204
TypeSmall organic molecule
Emp. Form.C28H23Cl3O4S
Mol. Mass.561.904
SMILESCCOC(=O)Cc1ccc(Cl)c(SC2=C(O)CC(CC2=O)c2c(Cl)ccc(c2Cl)-c2ccccc2)c1 |c:13|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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