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Target
Proteinase-activated receptor 2
Ligand
BDBM50091328
Substrate
n/a
Meas. Tech.
ChEMBL_1497755 (CHEMBL3583014)
IC50
2.0±n/a nM
Citation
 Abdel-Magid, AF Inhibitors of the PAR-2 Signaling Pathway May Treat Pain and Inflammation. ACS Med Chem Lett 6:487-8 (2015) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50091328
Synonyms:
CHEMBL3582250
Type:
Small organic molecule
Emp. Form.:
C27H28FN5O2S
Mol. Mass.:
505.607
SMILES:
CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN([C@@H](C)C1)C(=O)Cc1ccsc1)-c1ccc(F)cc1 |r|
Structure:
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