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TargetMonocarboxylate transporter 1 (MCT1)
LigandBDBM4345
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498543
IC50 140±n/a nM
Citation Gurrapu, SJonnalagadda, SKAlam, MANelson, GLSneve, MGDrewes, LRMereddy, VR Monocarboxylate transporter 1 inhibitors as potential anticancer agents. ACS Med Chem Lett6:558-61 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monocarboxylate transporter 1 (MCT1)
Name:Monocarboxylate transporter 1 (MCT1)
Synonyms:MCT 1 | Mct1 | Monocarboxylate transporter 1 | Slc16a1 | Solute carrier family 16 member 1
Type:Enzyme
Mol. Mass.:53245.17
Organism:Rattus norvegicus (Rat)
Description:P53987
Residue:494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM4345
NameBDBM4345
Synonyms:(2E)-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enoic acid | benzylidenemalononitrile (BMN) deriv. 29
TypeSmall organic molecule
Emp. Form.C12H12N2O2
Mol. Mass.216.2359
SMILESCN(C)c1ccc(\C=C(/C#N)C(O)=O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a