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TargetMonocarboxylate transporter 1 (MCT1)
LigandBDBM50092067
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498543
IC50 29±n/a nM
Citation Gurrapu, SJonnalagadda, SKAlam, MANelson, GLSneve, MGDrewes, LRMereddy, VR Monocarboxylate transporter 1 inhibitors as potential anticancer agents. ACS Med Chem Lett6:558-61 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Monocarboxylate transporter 1 (MCT1)
Name:Monocarboxylate transporter 1 (MCT1)
Synonyms:MCT 1 | Mct1 | Monocarboxylate transporter 1 | Slc16a1 | Solute carrier family 16 member 1
Type:Enzyme
Mol. Mass.:53245.17
Organism:Rattus norvegicus (Rat)
Description:P53987
Residue:494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
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  Blast E-value cutoff:
BDBM50092067
n/a
NameBDBM50092067
Synonyms:CHEMBL3582424 | US9296728, 16
TypeSmall organic molecule
Emp. Form.C17H18N2O3
Mol. Mass.298.3364
SMILESCOc1cc(ccc1\C=C(/C#N)C(O)=O)N(CC=C)CC=C
Structure
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