Reaction Details Report a problem with these data
Target
Estrogen-related receptor gamma
Ligand
BDBM22438
Substrate
n/a
Meas. Tech.
ChEMBL_1501351 (CHEMBL3588215)
Kd
5000±n/a nM
Citation
 Xu, S; Mao, L; Ding, P; Zhuang, X; Zhou, Y; Yu, L; Liu, Y; Nie, T; Xu, T; Xu, Y; Liu, J; Smaill, J; Ren, X; Wu, D; Ding, K 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor¿ and promote the browning of white adipose. Bioorg Med Chem 23:3751-60 (2015) [PubMed]  Article 
Target
Name:
Estrogen-related receptor gamma
Synonyms:
ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Type:
PROTEIN
Mol. Mass.:
51305.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1501351
Residue:
458
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM22438
Synonyms:
4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-hydrazide | 4-hydroxy-N'-[(1E)-[4-(propan-2-yl)phenyl]methylidene]benzohydrazide | GSK 4716 | GSK4716
Type:
Small organic molecule
Emp. Form.:
C17H18N2O2
Mol. Mass.:
282.337
SMILES:
CC(C)c1ccc(\C=N\NC(=O)c2ccc(O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: