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TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)
LigandBDBM50094237
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1502709
EC50 9700±n/a nM
Citation Penthala, NRCrooks, PAFreeman, MLSekhar, KR Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorg Med Chem23:3681-6 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)
Name:NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:32552.99
Organism:Homo sapiens (Human)
Description:ChEMBL_1502715
Residue:294
Sequence:
MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV
EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE
EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD
FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG
PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50094237
NameBDBM50094237
Synonyms:CHEMBL593574
TypeSmall organic molecule
Emp. Form.C21H14N4O3
Mol. Mass.370.3609
SMILESO=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2cn(-[#6]-c3ccc(cc3)C#N)c3ccccc23)-[#6](=O)-[#7]-1
Structure
n/a