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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50094464
Substrate
n/a
Meas. Tech.
ChEMBL_1503902 (CHEMBL3593135)
IC50
<0.300000±n/a nM
Citation
 Ward, RA; Colclough, N; Challinor, M; Debreczeni, JE; Eckersley, K; Fairley, G; Feron, L; Flemington, V; Graham, MA; Greenwood, R; Hopcroft, P; Howard, TD; James, M; Jones, CD; Jones, CR; Renshaw, J; Roberts, K; Snow, L; Tonge, M; Yeung, K Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem 58:4790-801 (2015) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50094464
Synonyms:
CHEMBL3590107 | US10525036, Example SCH772984 | US10934304, Example SCH772984
Type:
Small organic molecule
Emp. Form.:
C33H33N9O2
Mol. Mass.:
587.6742
SMILES:
O=C(CN1CC[C@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Structure:
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