Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50096196
Substrate
n/a
Meas. Tech.
ChEMBL_1505693 (CHEMBL3594613)
IC50
1380±n/a nM
Citation
 Abdullah, I; Chee, CF; Lee, YK; Thunuguntla, SS; Satish Reddy, K; Nellore, K; Antony, T; Verma, J; Mun, KW; Othman, S; Subramanya, H; Rahman, NA Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Bioorg Med Chem 23:4669-80 (2015) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50096196
Synonyms:
CHEMBL3593802
Type:
Small organic molecule
Emp. Form.:
C23H19N3O3
Mol. Mass.:
385.4153
SMILES:
CC(=O)Nc1cccc(c1)-c1ccc(cc1)-c1nc2c(cc(C)cc2[nH]1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: