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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50096148
Substrate
n/a
Meas. Tech.
ChEMBL_1505693 (CHEMBL3594613)
IC50
31000±n/a nM
Citation
 Abdullah, I; Chee, CF; Lee, YK; Thunuguntla, SS; Satish Reddy, K; Nellore, K; Antony, T; Verma, J; Mun, KW; Othman, S; Subramanya, H; Rahman, NA Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH. Bioorg Med Chem 23:4669-80 (2015) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50096148
Synonyms:
CHEMBL3593992
Type:
Small organic molecule
Emp. Form.:
C27H28N4O2
Mol. Mass.:
440.5368
SMILES:
NC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)-c1ccc(OCCN2CCCCC2)cc1
Structure:
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