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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50097854
Substrate
n/a
Meas. Tech.
ChEMBL_1502248 (CHEMBL3591184)
IC50
68±n/a nM
Citation
 Falke, H; Chaikuad, A; Becker, A; Loaëc, N; Lozach, O; Abu Jhaisha, S; Becker, W; Jones, PG; Preu, L; Baumann, K; Knapp, S; Meijer, L; Kunick, C 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem 58:3131-43 (2015) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4_MOUSE | Clk4
Type:
PROTEIN
Mol. Mass.:
57374.39
Organism:
Mus musculus
Description:
ChEMBL_1502248
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKRK
  
Inhibitor
Name:
BDBM50097854
Synonyms:
CHEMBL3589665
Type:
Small organic molecule
Emp. Form.:
C17H11ClN2O3
Mol. Mass.:
326.734
SMILES:
COc1ccc2c3[nH]c4c(Cl)cccc4c3c(nc2c1)C(O)=O
Structure:
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