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Target
Plasmepsin V
Ligand
BDBM50099252
Substrate
n/a
Meas. Tech.
ChEMBL_1459716 (CHEMBL3370434)
IC50
>20000±n/a nM
Citation
 Sleebs, BE; Gazdik, M; O'Neill, MT; Rajasekaran, P; Lopaticki, S; Lackovic, K; Lowes, K; Smith, BJ; Cowman, AF; Boddey, JA Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax. J Med Chem 57:7644-62 (2014) [PubMed]  Article 
Target
Name:
Plasmepsin V
Synonyms:
Plasmepsin V
Type:
PROTEIN
Mol. Mass.:
68485.65
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_109726
Residue:
590
Sequence:
MNNYFLRKENFFILFCFVFVSIFFVSNVTIIKCNNVENKIDNVGKKIENVGKKIGDMENKNDNVENKNDNVGNKNDNVKNASSDLYKYKLYGDIDEYAYYFLDIDIGKPSQRISLILDTGSSSLSFPCNGCKDCGIHMEKPYNLNYSKTSSILYCNKSNCPYGLKCVGNKCEYLQSYCEGSQIYGFYFSDIVTLPSYNNKNKISFEKLMGCHMHEESLFLHQQATGVLGFSLTKPNGVPTFVDLLFKHTPSLKPIYSICVSEHGGELIIGGYEPDYFLSNQKEKQKMDKSDNNSSNKGNVSIKLKNNDKNDDEENNSKDVIVSNNVEDIVWQAITRKYYYYIKIYGLDLYGTNIMDKKELDMLVDSGSTFTHIPENIYNQINYYLDILCIHDMTNIYEINKRLKLTNESLNKPLVYFEDFKTALKNIIQNENLCIKIVDGVQCWKSLENLPNLYITLSNNYKMIWKPSSYLYKKESFWCKGLEKQVNNKPILGLTFFKNKQVIFDLQQNQIAFIESKCPSNLTSSRPRTFNEYREKENIFLKVSYINLYCLWLLLALTILLSLILYVRKMFYMDYFPLSDQNKSPIQEST
  
Inhibitor
Name:
BDBM50099252
Synonyms:
CHEMBL3344163
Type:
Small organic molecule
Emp. Form.:
C36H56F3N7O8
Mol. Mass.:
771.8671
SMILES:
OC(=O)C(F)(F)F.C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)CC(=O)NC1CCCCC1 |r|
Structure:
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