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Target
Proteasome subunit beta type-10
Ligand
BDBM50099688
Substrate
n/a
Meas. Tech.
ChEMBL_1446811 (CHEMBL3371285)
IC50
>10000±n/a nM
Citation
 de Bruin, G; Huber, EM; Xin, BT; van Rooden, EJ; Al-Ayed, K; Kim, KB; Kisselev, AF; Driessen, C; van der Stelt, M; van der Marel, GA; Groll, M; Overkleeft, HS Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes. J Med Chem 57:6197-209 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50099688
Synonyms:
CHEMBL3319581
Type:
Small organic molecule
Emp. Form.:
C32H45N5O6
Mol. Mass.:
595.7296
SMILES:
C[C@@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC1CCCCC1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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