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TargetGABA transporter 3
LigandBDBM50101329
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1454198
IC50 76300±n/a nM
Citation Kobayashi, TSuemasa, AIgawa, AIde, SFukuda, HAbe, HArisawa, MMinami, MShuto, S Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett5:889-93 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GABA transporter 3
Name:GABA transporter 3
Synonyms:GAT-3 | Solute carrier family 6 member 11
Type:PROTEIN
Mol. Mass.:70607.60
Organism:Homo sapiens (Human)
Description:ChEMBL_1454198
Residue:632
Sequence:
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50101329
NameBDBM50101329
Synonyms:CHEMBL3326391
TypeSmall organic molecule
Emp. Form.C7H11NO2
Mol. Mass.141.1677
SMILES[H][C@@]12C[C@]1(N)CC[C@@H]2C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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