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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50101449
Substrate
n/a
Meas. Tech.
ChEMBL_1460519 (CHEMBL3395429)
IC50
5220±n/a nM
Citation
 Bie, J; Liu, S; Li, Z; Mu, Y; Xu, B; Shen, Z Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Eur J Med Chem 90:394-405 (2015) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM50101449
Synonyms:
CHEMBL3393945
Type:
Small organic molecule
Emp. Form.:
C19H16N2O7
Mol. Mass.:
384.3395
SMILES:
COc1cccc(c1)-c1ccc([N+]([O-])=O)c2[nH]c(C(O)=O)c(CCC(O)=O)c12
Structure:
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