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Target
Cyclin-dependent kinase 2
Ligand
BDBM50102667
Substrate
n/a
Meas. Tech.
ChEMBL_1443101 (CHEMBL3380807)
IC50
>30000±n/a nM
Citation
 Doig, P; Boriack-Sjodin, PA; Dumas, J; Hu, J; Itoh, K; Johnson, K; Kazmirski, S; Kinoshita, T; Kuroda, S; Sato, TO; Sugimoto, K; Tohyama, K; Aoi, H; Wakamatsu, K; Wang, H Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg Med Chem 22:6256-69 (2014) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50102667
Synonyms:
CHEMBL3343042
Type:
Small organic molecule
Emp. Form.:
C29H26N6O3
Mol. Mass.:
506.5551
SMILES:
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)nc(NCCc3ccccn3)nc2cc1O
Structure:
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