Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM82898
Substrate
n/a
Meas. Tech.
ChEMBL_1482571 (CHEMBL3537392)
IC50
33300±n/a nM
Citation
 Wolman, AT; Gionfriddo, MR; Heindel, GA; Mukhija, P; Witkowski, S; Bommareddy, A; Vanwert, AL Organic anion transporter 3 interacts selectively with lipophilicß-lactam antibiotics. Drug Metab Dispos 41:791-800 (2013) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Oat3 | Oat3 | Organic anion transporter 3 | Reduced in osteosclerosis transporter | Roct | S22A8_MOUSE | Slc22a8 | Solute carrier family 22 member 8 | mOat3
Type:
PROTEIN
Mol. Mass.:
59254.18
Organism:
Mus musculus
Description:
ChEMBL_104613
Residue:
537
Sequence:
MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGPNGKPEKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIEDIQDWYQQTKKTKQEPEAEKASQTIPLKTGGP
  
Inhibitor
Name:
BDBM82898
Synonyms:
(6R,7R)-3-(acetoxymethyl)-8-keto-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-(acetyloxymethyl)-8-oxidanylidene-7-(2-thiophen-2-ylethanoylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(1-oxo-2-thiophen-2-ylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | Cephalothin | MLS001048966 | SMR000386987 | cid_6024
Type:
Small organic molecule
Emp. Form.:
C16H16N2O6S2
Mol. Mass.:
396.438
SMILES:
CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc1cccs1)C2=O)C(O)=O |t:5|
Structure:
Search PDB for entries with ligand similarity: