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Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
LigandBDBM50445946
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1435600
IC50 207±n/a nM
Citation Granchi, CFancelli, DMinutolo, F An update on therapeutic opportunities offered by cancer glycolytic metabolism. Bioorg Med Chem Lett24:4915-25 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Name:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)
Synonyms:6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2
Type:Enzyme
Mol. Mass.:59620.59
Organism:Homo sapiens (Human)
Description:Q16875
Residue:520
Sequence:
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50445946
NameBDBM50445946
Synonyms:CHEMBL3105836
TypeSmall organic molecule
Emp. Form.C17H12N2O
Mol. Mass.260.29
SMILESO=C(\C=C\c1ccc2ccccc2n1)c1ccncc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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