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Target
Retinol-binding protein 4
Ligand
BDBM50104157
Substrate
n/a
Meas. Tech.
ChEMBL_1505277 (CHEMBL3594967)
IC50
6.3±n/a nM
Citation
 Cioffi, CL; Racz, B; Freeman, EE; Conlon, MP; Chen, P; Stafford, DG; Schwarz, DM; Zhu, L; Kitchen, DB; Barnes, KD; Dobri, N; Michelotti, E; Cywin, CL; Martin, WH; Pearson, PG; Johnson, G; Petrukhin, K Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease. J Med Chem 58:5863-88 (2015) [PubMed]  Article 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM50104157
Synonyms:
CHEMBL3594231
Type:
Small organic molecule
Emp. Form.:
C21H22F3N3O2
Mol. Mass.:
405.4135
SMILES:
[H][C@@]12C[C@@H](C[C@]1([H])CN(C2)c1nc(C)cc(n1)C(=O)OC)c1ccccc1C(F)(F)F |r|
Structure:
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