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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50106214
Substrate
n/a
Meas. Tech.
ChEMBL_1506408 (CHEMBL3599704)
EC50
776±n/a nM
Citation
 Han, S; Narayanan, S; Kim, SH; Calderon, I; Zhu, X; Kawasaki, A; Yue, D; Lehmann, J; Wong, A; Buzard, DJ; Semple, G; Carroll, C; Chu, ZL; Al-Sharmma, H; Shu, HH; Tung, SF; Unett, DJ; Behan, DP; Yoon, WH; Morgan, M; Usmani, KA; Chen, C; Sadeque, A; Leonard, JN; Jones, RM Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. Bioorg Med Chem Lett 25:3034-8 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50106214
Synonyms:
CHEMBL3598107
Type:
Small organic molecule
Emp. Form.:
C18H26F3N3O4S
Mol. Mass.:
437.477
SMILES:
CS(=O)(=O)c1cnc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC(F)(F)F)CC2)cn1 |r,wU:9.8,wD:12.15,(9.06,2.18,;8,1.56,;9.07,.95,;7.99,2.79,;6.67,.78,;6.67,-.76,;5.34,-1.53,;4,-.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;-2.67,1.54,;-2.66,3.08,;-4,3.86,;-3.99,5.4,;-2.65,6.16,;-2.65,7.7,;-1.31,8.47,;-1.3,9.7,;-.24,7.85,;-.24,9.08,;-1.32,5.39,;-1.33,3.85,;4,.77,;5.33,1.55,)|
Structure:
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