Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50106211
Substrate
n/a
Meas. Tech.
ChEMBL_1506410 (CHEMBL3599706)
EC50
29±n/a nM
Citation
 Han, S; Narayanan, S; Kim, SH; Calderon, I; Zhu, X; Kawasaki, A; Yue, D; Lehmann, J; Wong, A; Buzard, DJ; Semple, G; Carroll, C; Chu, ZL; Al-Sharmma, H; Shu, HH; Tung, SF; Unett, DJ; Behan, DP; Yoon, WH; Morgan, M; Usmani, KA; Chen, C; Sadeque, A; Leonard, JN; Jones, RM Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. Bioorg Med Chem Lett 25:3034-8 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50106211
Synonyms:
CHEMBL3598104
Type:
Small organic molecule
Emp. Form.:
C20H29F2N3O5S
Mol. Mass.:
461.523
SMILES:
CCC(F)(F)C(=O)N1CCC(CC1)O[C@H]1CC[C@@H](CC1)Oc1cnc(cn1)S(C)(=O)=O |r,wU:17.21,wD:14.14,(-.23,10.62,;-1.3,10.01,;-1.31,8.47,;-.24,9.08,;-.24,7.85,;-2.65,7.7,;-3.71,8.33,;-2.65,6.16,;-3.99,5.4,;-4,3.86,;-2.66,3.08,;-1.33,3.85,;-1.32,5.39,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;2.67,-1.54,;4,-.77,;4,.77,;5.33,1.55,;6.67,.78,;6.67,-.76,;5.34,-1.53,;8,1.56,;9.06,2.18,;9.07,.95,;7.99,2.79,)|
Structure:
Search PDB for entries with ligand similarity: