Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50106125
Substrate
n/a
Meas. Tech.
ChEMBL_1506410 (CHEMBL3599706)
EC50
56±n/a nM
Citation
 Han, SNarayanan, SKim, SHCalderon, IZhu, XKawasaki, AYue, DLehmann, JWong, ABuzard, DJSemple, GCarroll, CChu, ZLAl-Sharmma, HShu, HHTung, SFUnett, DJBehan, DPYoon, WHMorgan, MUsmani, KAChen, CSadeque, ALeonard, JNJones, RM Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. Bioorg Med Chem Lett 25:3034-8 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50106125
Synonyms:
CHEMBL3598113
Type:
Small organic molecule
Emp. Form.:
C22H33N5O5S
Mol. Mass.:
479.593
SMILES:
CC(C)c1nc(CN2CCC(CC2)O[C@H]2CC[C@@H](CC2)Oc2cnc(cn2)S(C)(=O)=O)no1 |r,wU:17.21,wD:14.14,(3.13,7.65,;2.64,8.78,;3.38,9.77,;1.11,8.96,;.08,7.82,;-1.31,8.47,;-2.65,7.7,;-2.65,6.16,;-3.99,5.4,;-4,3.86,;-2.66,3.08,;-1.33,3.85,;-1.32,5.39,;-2.67,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;2.67,-1.54,;4,-.77,;4,.77,;5.33,1.55,;6.67,.78,;6.67,-.76,;5.34,-1.53,;8,1.56,;9.06,2.18,;9.07,.95,;7.99,2.79,;-1.15,9.99,;.35,10.3,)|
Structure:
Search PDB for entries with ligand similarity: