Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50106426
Substrate
n/a
Meas. Tech.
ChEMBL_1508609 (CHEMBL3602720)
IC50
625±n/a nM
Citation
 Roth, GJ; Heckel, A; Kley, JT; Lehmann, T; Müller, SG; Oost, T; Rudolf, K; Arndt, K; Budzinski, R; Lenter, M; Lotz, RR; Schindler, M; Thomas, L; Stenkamp, D Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition. Bioorg Med Chem Lett 25:3270-4 (2015) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50106426
Synonyms:
CHEMBL3600976
Type:
Small organic molecule
Emp. Form.:
C28H29ClN2O
Mol. Mass.:
444.996
SMILES:
CN(C(=O)\C=C\c1ccc(cc1)-c1ccc(Cl)cc1)c1ccc(CN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: