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Target
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Ligand
BDBM50107272
Substrate
n/a
Meas. Tech.
ChEMBL_1508846 (CHEMBL3603395)
IC50
31623±n/a nM
Citation
 Raubo, P; Andrews, DM; McKelvie, JC; Robb, GR; Smith, JM; Swarbrick, ME; Waring, MJ Discovery of potent, selective small molecule inhibitors ofa-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIa). Bioorg Med Chem Lett 25:3189-93 (2015) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Synonyms:
KIAA0589 | PI51C_HUMAN | PIP5K1-gamma | PIP5K1C | PIP5KIgamma | Phosphatidylinositol 4-phosphate 5-kinase type I gamma | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | PtdIns(4)P-5-kinase 1 gamma
Type:
PROTEIN
Mol. Mass.:
73241.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508846
Residue:
668
Sequence:
MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT
  
Inhibitor
Name:
BDBM50107272
Synonyms:
CHEMBL3600698
Type:
Small organic molecule
Emp. Form.:
C15H15N3OS
Mol. Mass.:
285.364
SMILES:
CC(C)Oc1cncc(c1)-c1ccc2nc(N)sc2c1
Structure:
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