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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50109022
Substrate
n/a
Meas. Tech.
ChEMBL_1508582 (CHEMBL3602665)
EC50
30±n/a nM
Citation
 Meena, CL; Thakur, A; Nandekar, PP; Sangamwar, AT; Sharma, SS; Jain, R Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice. Bioorg Med Chem 23:5641-53 (2015) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R2 | Thyrotropin-releasing hormone receptor 2
Type:
PROTEIN
Mol. Mass.:
27545.04
Organism:
Mus musculus
Description:
ChEMBL_109850
Residue:
251
Sequence:
MDGPSNVSLVHGDTTLGLPEYKVVSVLLVLLVCTVGIVGNAMVVLVVLTSRDMHTPTNCYLVSLALADLIVLLAAGLPNVSDSLVGHWIYGHAGCLGITYFQYLGINVSSCSILAFTVERYIAICHPMRAQTVCTVARARRIIAGIWGVTSLYCLLWFFLVDLNVRDNQRLECGYKVSRGLYLPIYLLDFAVFFIAPLLGTLVLYGFIGRILFQSPLSQEAWQKERQSHGQSEGTPGNCSRSKSSMSSRKQ
  
Inhibitor
Name:
BDBM50109022
Synonyms:
CHEMBL3601785
Type:
Small organic molecule
Emp. Form.:
C17H20BrN7O3
Mol. Mass.:
450.29
SMILES:
Cn1cnc(C[C@H](NC(=O)c2cnccn2)C(=O)N2CCC[C@H]2C(N)=O)c1Br |r|
Structure:
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