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Target
Cyclin-dependent kinase 4
Ligand
BDBM50110179
Substrate
n/a
Meas. Tech.
ChEMBL_1510329 (CHEMBL3606997)
IC50
2.0±n/a nM
Citation
 Sánchez-Martínez, C; Gelbert, LM; Lallena, MJ; de Dios, A Cyclin dependent kinase (CDK) inhibitors as anticancer drugs. Bioorg Med Chem Lett 25:3420-35 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50110179
Synonyms:
CHEMBL190281
Type:
Small organic molecule
Emp. Form.:
C22H25BrN6O
Mol. Mass.:
469.378
SMILES:
Brc1cc2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n(C2CCCC2)c1=O
Structure:
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