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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50110893
Substrate
n/a
Meas. Tech.
ChEMBL_1511841 (CHEMBL3608043)
IC50
4470±n/a nM
Citation
 Ziemniak, M; Kowalska, J; Lukaszewicz, M; Zuberek, J; Wnek, K; Darzynkiewicz, E; Jemielity, J Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. Bioorg Med Chem 23:5369-81 (2015) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | IF4E_RABIT
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50110893
Synonyms:
CHEMBL3604538
Type:
Small organic molecule
Emp. Form.:
C12H35BN9O12P3
Mol. Mass.:
601.192
SMILES:
[NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O |r|
Structure:
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