Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50110895
Substrate
n/a
Meas. Tech.
ChEMBL_1511842 (CHEMBL3608168)
IC50
1240±n/a nM
Citation
 Ziemniak, M; Kowalska, J; Lukaszewicz, M; Zuberek, J; Wnek, K; Darzynkiewicz, E; Jemielity, J Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. Bioorg Med Chem 23:5369-81 (2015) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | IF4E_RABIT
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50110895
Synonyms:
CHEMBL3604540
Type:
Small organic molecule
Emp. Form.:
C12H32N9O12P3S
Mol. Mass.:
619.422
SMILES:
[NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Structure:
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