Target
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Ligand
BDBM50111158
Substrate
n/a
Meas. Tech.
ChEMBL_1509931 (CHEMBL3607749)
IC50
130±n/a nM
Citation
 Becherer, JDBoros, EECarpenter, TYCowan, DJDeaton, DNHaffner, CDJeune, MRKaldor, IWPoole, JCPreugschat, FRheault, TRSchulte, CAShearer, BGShearer, TWShewchuk, LMSmalley, TLStewart, ELStuart, JDUlrich, JC Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38. J Med Chem 58:7021-56 (2015) [PubMed]  Article 
Target
Name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Synonyms:
CD38 | CD38_HUMAN | Lymphocyte differentiation antigen CD38
Type:
PROTEIN
Mol. Mass.:
34333.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1509931
Residue:
300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
  
Inhibitor
Name:
BDBM50111158
Synonyms:
CHEMBL3604739
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2FN3O
Mol. Mass.:
378.228
SMILES:
Cc1cc(NCc2c(F)ccc(Cl)c2Cl)c2cccc(C(N)=O)c2n1
Structure:
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